Hydrochloric Acid → HCID 178455960, compound

HRID 1395819Notes

Reaction equation

HRID 1395819 reaction equation
[CH3:1][O:2][C:3](=[O:40])[C@H:4]([CH2:38][OH:39])[NH:5][C:6](=[O:37])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:36])[C@H:13]([CH2:30][C:31]1[N:35]=[CH:34][NH:33][CH:32]=1)[NH:14][C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH:17]C(OC(C)(C)C)=O.[ClH:41]>O1CCOCC1>[ClH:41].[CH3:1][O:2][C:3](=[O:40])[C@H:4]([CH2:38][OH:39])[NH:5][C:6](=[O:37])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:36])[C@H:13]([CH2:30][C:31]1[N:35]=[CH:34][NH:33][CH:32]=1)[NH:14][C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH2:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178455967HCID 178455967, compound

Product 1

HCID 178455960HCID 178455960, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

8.5 g of t-butoxycarbonylisoleucylhistidylprolylserine methyl ester is dissolved in 51 ml of dioxane. To this solution is added 25.5 ml of 6 N hydrochloric acid in dioxane. The reaction is allowed to stand for ten minutes and the solvent is removed under vacuum to afford isoleucylhistidylprolylserine methyl ester hydrochloride.

Workup

  1. waitto stand for ten minutes
  2. customthe solvent is removed under vacuum

Sources & evidence

ORD record
ord-822003db699843fabbe710af602cfa63
Source dataset
uspto-grants-1980_05
Patent number
US04204991

Reaction notes

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