Acetonitrile → tert-butyl 1-(2-(7-cyano-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-ylcarbamate
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1.[CH3:74][C:75]#[N:76].[K:29][C:30]#[N:31].[O:115]=[C:116]([CH:117]=[CH:118][c:119]1[cH:120][cH:121][cH:122][cH:123][cH:124]1)[CH:125]=[CH:126][c:127]1[cH:128][cH:129][cH:130][cH:131][cH:132]1.[O:79]=[C:80]([CH:81]=[CH:82][c:83]1[cH:84][cH:85][cH:86][cH:87][cH:88]1)[CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1.[O:97]=[C:98]([CH:99]=[CH:100][c:101]1[cH:102][cH:103][cH:104][cH:105][cH:106]1)[CH:107]=[CH:108][c:109]1[cH:110][cH:111][cH:112][cH:113][cH:114]1.[Pd:77].[Pd:78].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[c:41]3[c:65]([cH:66][cH:67][cH:68]2)[C:62]([CH3:63])([CH3:64])[c:44]2[c:43]([c:48]([P:49]([c:50]4[cH:51][cH:52][cH:53][cH:54][cH:55]4)[c:56]4[cH:57][cH:58][cH:59][cH:60][cH:61]4)[cH:47][cH:46][cH:45]2)[O:42]3)[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[c:2]1([C:30]#[N:31])[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-3c7b5e67f41142eba22bb157e64646d1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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