Ammonia → 6-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

HRID 1396357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1396357
C([O:3][C:4]([C:6]1[N:7]=[N:8][C:9]([Cl:20])=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=1)=O)C.[NH3:21]>CO>[Cl:20][C:9]1[N:8]=[N:7][C:6]([C:4]([NH2:21])=[O:3])=[C:11]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=2)[CH:10]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 866897246-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester

Produkt 1

HCID 866897076-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester (137 mg, 0.468 mmol) was suspended in 7M ammonia in methanol (3 mL). After 4 h, the reaction mixture was concentrated in vacuo to give 6-chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (123 mg, 100%) as an off-white solid which was used directly in the next step without purification. LCMS (EI/CI) m/z: 264 [M+H].

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c1027a3c8b944b16895416068350ee1c
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901124B2

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