Ammonia → 6-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Participants

Reaction Steps

6-Chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester (137 mg, 0.468 mmol) was suspended in 7M ammonia in methanol (3 mL). After 4 h, the reaction mixture was concentrated in vacuo to give 6-chloro-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (123 mg, 100%) as an off-white solid which was used directly in the next step without purification. LCMS (EI/CI) m/z: 264 [M+H].

Provenance & Evidence