Ammonia → HCID 86689739, compound

HRID 1396377Notes

Reaction equation

HRID 1396377 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][C:9]([Cl:21])=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][CH3:20])[N:14]=1)=O)C.[NH3:22]>CO>[Cl:21][C:9]1[N:8]=[N:7][C:6]([C:4]([NH2:22])=[O:3])=[C:11]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][CH3:20])[N:14]=2)[CH:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86689738HCID 86689738, compound

Product 1

HCID 86689739HCID 86689739, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloro-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester (241 mg, 0.786 mmol) was suspended in 7M ammonia in methanol (9 mL). After 3 h, the reaction mixture was concentrated in vacuo to give 6-chloro-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (218 mg, 100%) as an off-white solid which was used directly in the next step without purification. LCMS (EI/CI) m/z: 278 [M+H].

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a68f0a49764d47abb87e82729d41fb13
Source dataset
uspto-grants-2014_12
Patent number
US08901124B2

Reaction notes

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