Ammonia → 6-Chloro-4-(5,6-dimethoxypyridin-2-ylamino)pyridazine-3-carboxamide

HRID 1396389Notes

Reaction equation

HRID 1396389 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[N:7][C:8]([Cl:22])=[CH:9][C:10]=1[NH:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[N:13]=1)=O.CO.[NH3:25]>>[Cl:22][C:8]1[N:7]=[N:6][C:5]([C:3]([NH2:25])=[O:2])=[C:10]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[N:13]=2)[CH:9]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 866897456-Chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester

Product 1

HCID 866897466-Chloro-4-(5,6-dimethoxypyridin-2-ylamino)pyridazine-3-carboxamideYield 96%

Procedure

6-Chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester (1.7 g, 5.2 mmol) was suspended in ammonia in methanol (7N, 30.0 mL, 210 mmol) and the flask sealed. After stirring for 6 h at room temperature the mixture was concentrated in vacuo to give 6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (1.55 g, 96%) as a yellow powder. LC-MS: 310.4 [M+H]+.

Workup

  1. customthe flask sealed
  2. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-32ddf3bdf38c4758903de376dd82782e
Source dataset
uspto-grants-2014_12
Patent number
US08901124B2

Reaction notes

Loading…