Ammonia → 6-Chloro-4-(5,6-dimethoxypyridin-2-ylamino)pyridazine-3-carboxamide

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Reaction Steps

6-Chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester (1.7 g, 5.2 mmol) was suspended in ammonia in methanol (7N, 30.0 mL, 210 mmol) and the flask sealed. After stirring for 6 h at room temperature the mixture was concentrated in vacuo to give 6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (1.55 g, 96%) as a yellow powder. LC-MS: 310.4 [M+H]+.

Provenance & Evidence