Ammonia → 3-(3-Fluoro-4-methoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

HRID 1396539Notes

Reaction equation

HRID 1396539 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[C:18]3[C:13](=[N:14][C:15](S(C)(=O)=O)=[N:16][CH:17]=3)[N:12]([CH3:23])[N:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[NH3:24]>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[C:18]3[C:13](=[N:14][C:15]([NH2:24])=[N:16][CH:17]=3)[N:12]([CH3:23])[N:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 689654983-(3-Fluoro-4-methoxy-phenyl)-6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 235823063-(3-Fluoro-4-methoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(3-Fluoro-4-methoxy-phenyl)-6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (0.8 g, 2.3 mmol) is dissolved in a saturated solution of ammonia in THF in an autoclave and the reaction mixture is stirred at room temperature for 2-18 hours. The solvent is removed in vacuo and the resulting solid is suspended in methanol, stirred at room temperature for 30 minutes and collected by filtration to afford the title compound as a white solid.

Workup

  1. customThe solvent is removed in vacuo
  2. stirringstirred at room temperature for 30 minutes
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-81941b94970b45c483fb3be0e036a39f
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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