反应详情

3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Intermediate 3) (0.1 g, 0.44 mmol), 2-methoxy-5-trifluoromethylphenylboronic acid (0.116 g, 0.53 mmol), Pd(dppf)Cl2 (0.032 g, 0.044 mmol), DME (4 ml) and 2M aqueous Na2CO3, are mixed together and heated using microwave radiation at 100° C. for 30 minutes. The reaction mixture is diluted with EtOAc (30 mls), MgSO4 is added and the resulting mixture is filtered through Celite® (filter agent), washing with EtOAc. The reaction mixture is absorbed onto silica and purification by flash chromatography on silica eluting with DCM then MeOH:DCM (5:95) affords the title compound.

1. temperatureheated
2. customat 100° C.
3. customfor 30 minutes
4. additionis added
5. filtrationthe resulting mixture is filtered through Celite® (filter agent)
6. washwashing with EtOAc
7. customThe reaction mixture is absorbed onto silica and purification by flash chromatography on silica eluting with DCM