Ammonia → 3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

HRID 1396571Notes

Reaction equation

HRID 1396571 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[N:6][C:7](S(C)(=O)=O)=[N:8][CH:9]=2)[N:4]([CH3:15])[N:3]=1.[NH3:16]>O1CCOCC1>[Br:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([NH2:16])=[N:8][CH:9]=2)[N:4]([CH3:15])[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 210980553-Bromo-6-(methanesulfonyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 689626923-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Bromo-6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (WO 2003029209, page 46) (0.215 g, 0.0074 mol) is dissolved in 0.5M ammonia in 1,4-dioxane (11 ml) and stirred overnight at room temperature. The reaction mixture is concentrated in vacuo to afford the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-9a78d36c30df445084e513a56153fb0d
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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