HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Bromo-6-(methanesulfonyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine | HCID 21098055 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine | HCID 68962692 | — |
Reaction Steps
3-Bromo-6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (WO 2003029209, page 46) (0.215 g, 0.0074 mol) is dissolved in 0.5M ammonia in 1,4-dioxane (11 ml) and stirred overnight at room temperature. The reaction mixture is concentrated in vacuo to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901134B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-9a78d36c30df445084e513a56153fb0d |
| Source note | uspto-grants-2014_12 |