Formamide → HCID 178518017, 화합물

HRID 1396584노트

반응식

HRID 1396584 반응식
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:11]([NH2:13])=O>>[N:1]1[C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[C:8]([OH:10])=[N:13][CH:11]=1

참가 물질

3

반응물 2

HCID 713FormamideHCID 738363-Aminopicolinic acid

생성물 1

HCID 178518017HCID 178518017, 화합물

반응 조건

온도
170 °C

실험 절차

3-Aminopicolinic acid (B-1) (30 g, 217 mmol, 1.0 eq) is suspended in formamide (75 mL, 1.88 mol, 8.66 eq). The resulting mixture is stirred at 140° C. for 1 h and at 170° C. for 1 h and then at 180° C. for an additional 1 h. The mixture is cooled to RT and filtered. The filter cake is washed with water, and dried in vacuo to afford the product, pyrido[3,2-d]pyrimidin-4-ol (B-2).

후처리

  1. waitat 180° C. for an additional 1 h
  2. temperatureThe mixture is cooled to RT
  3. filtrationfiltered
  4. washThe filter cake is washed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-de426438823a40f3bfe0dbc95b24208b
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901133B2

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