HCID 86665019, compound → HCID 178479634, compound

HRID 1396591Notes

Reaction equation

HRID 1396591 reaction equation
C([O:8][C:9]1[C:10]2[N:11]([CH:16]=[CH:17][N:18]=2)[N:12]=[C:13]([Cl:15])[CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[ClH:15].[N:18]1[CH:17]=[CH:16][N:11]2[C:10]=1[C:9]([OH:8])=[CH:14][CH:13]=[N:12]2

Participants

4

Reactant 1

HCID 86665019HCID 86665019, compound

Product 1

HCID 178479634HCID 178479634, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a stirred solution of 8-(benzyloxy)-6-chloroimidazo[1,2-b]pyridazine (D-4) (6.2 g, 23.8 mmol, 1.0 eq) in MeOH (100 mL), Pd/C (10%, 620 mg) is added. The resulting mixture is degassed and back-filled with hydrogen three times and then stirred at 50° C. under hydrogen for 24 h. The resulting mixture is filtered and concentrated in vacuo to afford the product, imidazo[1,2-b]pyridazin-8-ol hydrochloride (D-5).

Workup

  1. customThe resulting mixture is degassed
  2. additionback-filled with hydrogen three times
  3. filtrationThe resulting mixture is filtered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-21f2984653484c269a6b05a2fcb53c52
Source dataset
uspto-grants-2014_12
Patent number
US08901133B2

Reaction notes

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