HCID 86665019, compound → HCID 178479634, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 8-(benzyloxy)-6-chloroimidazo[1,2-b]pyridazine (D-4) (6.2 g, 23.8 mmol, 1.0 eq) in MeOH (100 mL), Pd/C (10%, 620 mg) is added. The resulting mixture is degassed and back-filled with hydrogen three times and then stirred at 50° C. under hydrogen for 24 h. The resulting mixture is filtered and concentrated in vacuo to afford the product, imidazo[1,2-b]pyridazin-8-ol hydrochloride (D-5).

Provenance & Evidence