Ammonia → HCID 56973649, compound

HRID 1396633Notes

Reaction equation

HRID 1396633 reaction equation
[Br:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1.[NH3:12]>C(O)C>[NH2:12][C:8]1[CH:9]=[C:2]([Br:1])[CH:3]=[C:4]([F:11])[C:5]=1[C:6]#[N:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27569164-Bromo-2,6-difluorobenzonitrile

Product 1

HCID 56973649HCID 56973649, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.0 g (22.9 mmol) 4-bromo-2,6-difluorobenzonitrile in 200 ml of a solution of NH3 in ethanol and heated in a pressure vessel to 90° C. for 20 h. After cooling to RT the solvent is evaporated and the residue taken up in water/DCM. The organic phase is separated, dried and evaporated.

Workup

  1. customis evaporated
  2. customThe organic phase is separated
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-592d1687910c4f5ebc77d279a5c7656a
Source dataset
uspto-grants-2014_12
Patent number
US08901138B2

Reaction notes

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