Dimethylformamide dimethyl acetal → HCID 75201679, compound

HRID 1396634Notes

Reaction equation

HRID 1396634 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([F:11])[C:3]=1[C:4]#[N:5].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Br:10][C:8]1[CH:7]=[C:6]([F:11])[C:3]([C:4]#[N:5])=[C:2]([N:1]=[CH:14][N:15]([CH3:17])[CH3:16])[CH:9]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 56973649HCID 56973649, compound

Product 1

HCID 75201679HCID 75201679, compound

Procedure

17.0 g (79.1 mmol) 2-amino-4-bromo-6-fluoro-benzonitrile in 140 ml of N,N-dimethylformamide dimethyl acetal are heated to 120° C. for 2 h. After cooling RT the solvent is evaporated and the residue taken up in diethyl ether, filtered and dried.

Workup

  1. customis evaporated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-7afef658fa3542de9408bed6e4a555ba
Source dataset
uspto-grants-2014_12
Patent number
US08901138B2

Reaction notes

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