Hydrochloric Acid → HCID 86701152, compound

HRID 1396652Notes

Reaction equation

HRID 1396652 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([NH:8][C:9](=[O:22])[C:10]3[N:11]2[C:14]([CH:17]2[CH2:21][CH2:20][O:19][CH2:18]2)=[N:15][CH:16]=3)=[CH:6][C:5]=1[C:23]([O:25]C)=[O:24].[OH-].[Na+].Cl>CO>[CH3:1][O:2][CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([NH:8][C:9](=[O:22])[C:10]3[N:11]2[C:14]([CH:17]2[CH2:21][CH2:20][O:19][CH2:18]2)=[N:15][CH:16]=3)=[CH:6][C:5]=1[C:23]([OH:25])=[O:24]

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 14798Sodium HydroxideHCID 66696247HCID 66696247, compound

Product 1

HCID 86701152HCID 86701152, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

To a mixture of 4.54 g of methyl 8-(methoxymethyl)-4-oxo-1-(tetrahydrofuran-3-yl)-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxylate and 45.0 mL of methanol was added 17.0 mL of a 3 M aqueous sodium hydroxide solution, followed by stirring at 70° C. for 5 hours. Concentrated hydrochloric acid and 1 M hydrochloric acid were added thereto to adjust the pH to about 3, and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 4.31 g of 8-(methoxymethyl)-4-oxo-1-(tetrahydrofuran-3-yl)-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxylic acid as a white solid.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-2eab2bf2805e4a4e9eee187ef2b3e199
Source dataset
uspto-grants-2014_12
Patent number
US08901126B2

Reaction notes

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