反应详情

温度

70 °C

To a mixture of 12.7 g of methyl 3-chloro-7-methyl-2-[2-(tetrahydro-2H-pyran-4-ylcarbonyl)hydrazino]quinoxaline-6-carboxylate and 250 mL of tetrahydrofuran was added 5 mL of thionyl chloride, followed by stirring at 70° C. overnight. After cooling to room temperature, the solvent was evaporated under reduced pressure and the obtained solid was washed with diethyl ether to obtain 10.4 g of methyl 4-chloro-8-methyl-1-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate as a pale yellow solid.

1. temperatureAfter cooling to room temperature
2. customthe solvent was evaporated under reduced pressure
3. washthe obtained solid was washed with diethyl ether