Clofibric Acid → HCID 66758025, compound

HRID 1396754Notes

Reaction equation

HRID 1396754 reaction equation
[N:1]1([C:7]2[C:8]3[N:16]=[C:15]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[S:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:23][C:24]1[CH:36]=[CH:35][C:27]([O:28][C:29]([CH3:34])([CH3:33])[C:30](O)=[O:31])=[CH:26][CH:25]=1>>[NH2:13][C:11]1[N:12]=[C:7]([N:1]2[CH2:6][CH2:5][N:4]([C:30](=[O:31])[C:29]([O:28][C:27]3[CH:35]=[CH:36][C:24]([Cl:23])=[CH:25][CH:26]=3)([CH3:34])[CH3:33])[CH2:3][CH2:2]2)[C:8]2[N:16]=[C:15]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[S:14][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 2797Clofibric AcidHCID 509420567-(Piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine

Product 1

HCID 66758025HCID 66758025, compoundYield 45%

Procedure

This compound was prepared from 7-(piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine using 2-(4-chlorophenoxy)-2-methylpropanoic acid in a yield of 45%, according to the procedure for the synthesis of example 50.

Workup

  1. customaccording to the procedure for the synthesis of example 50

Sources & evidence

ORD record
ord-552fad2c4fcd4bd0bc27c64ef75cadfb
Source dataset
uspto-grants-2014_12
Patent number
US08901132B2

Reaction notes

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