Trifluoroacetic acid → HCID 56942175, compound

HRID 1396793Notes

Reaction equation

HRID 1396793 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:22][CH2:21][C@@H:20]([NH:23]C(=O)OC(C)(C)C)[CH2:19]2)[C:5]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[S:8][C:6]=2[N:7]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:23][C@@H:20]1[CH2:21][CH2:22][N:18]([C:4]2[C:5]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=4)[S:8][C:6]=3[N:7]=[C:2]([NH2:1])[N:3]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66758218HCID 66758218, compound

Product 1

HCID 56942175HCID 56942175, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound of example 338 (66 mg, 0.15 mmol) in dichloromethane (6 ml) was added trifluoroacetic acid (3 ml). The solution was stirred at room temperature for 30 minutes. The solvents were evaporated in vacuo and co-evaporated with toluene. The residue was directly used for further reaction without any purification.

Workup

  1. customThe solvents were evaporated in vacuo and co-evaporated with toluene
  2. customThe residue was directly used for further reaction without any purification

Sources & evidence

ORD record
ord-bf2f22587f1842488c647d303f7b7b06
Source dataset
uspto-grants-2014_12
Patent number
US08901132B2

Reaction notes

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