反应详情

A solution of 3-(1,1-dimethylethyl) 1,2-bis(phenylmethyl) 1,2,3-pyrazolidinetricarboxylate (2.00 kg, 4.54 mol) in 10 L methanol was charged into a 20 L four-necked round-bottomed flask under N2 (gas). Then 200 g Pd/C (10%, 65% water) was added carefully to the mixture solution. H2 (gas) was introduced to exchange N2 (gas) three times. The mixture solution was allowed to react at 25° C. under 1 atm of H2 for 8 h until the starting material was consumed completely. N2 (gas) was introduced to remove excess H2 (gas). A filtration was performed to remove the catalyst. The filtrate can be used in the next step without further purification.

1. additionH2 (gas) was introduced
2. customto react at 25° C. under 1 atm of H2 for 8 h until the starting material
3. customwas consumed completely
4. additionN2 (gas) was introduced
5. customto remove excess H2 (gas)
6. filtrationA filtration
7. customto remove the catalyst
8. customThe filtrate can be used in the next step without further purification