Hydrochloric Acid → 1-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid

HRID 1396847노트

반응식

HRID 1396847 반응식
[N:1]1([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[CH2:5][CH2:4][CH:3]([C:6]([O:8]C(C)(C)C)=[O:7])[NH:2]1.Cl.CCOCC>ClCCl>[C:17]1([CH2:16][O:15][C:13]([N:1]2[CH2:5][CH2:4][CH:3]([C:6]([OH:8])=[O:7])[NH:2]2)=[O:14])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 133415401-Benzyl 3-tert-butyl 1,3-pyrazolidinedicarboxylate

생성물 1

HCID 537448401-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

At r.t., to a 50 mL round bottomed flask containing crude 3-(1,1-dimethylethyl) 1-(phenylmethyl) 1,3-pyrazolidinedicarboxylate (88 mg) in dichloromethane (DCM) (0.5 mL), was added HCl in ether (2M) (3.59 mL, 7.18 mmol), then the reaction vessel was equipped with a glass stopper. The reaction mixture was stirred at r.t. for 48 hr. The solid was filtered and washed with ether, providing the product as an off-white solid. (58.4 mg, 71% over two steps).

후처리

  1. customthe reaction vessel was equipped with a glass stopper
  2. filtrationThe solid was filtered
  3. washwashed with ether

출처 및 근거

ORD 기록
ord-22189f3673584361bac01f71a883bb8c
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901119B2

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