Water → 1-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid

HRID 1396854노트

반응식

HRID 1396854 반응식
[N:1]1([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:5][CH2:4][CH:3]([C:6]([O:8]C(C)(C)C)=[O:7])[N:2]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O.O>ClCCl>[C:24]1([CH2:23][O:22][C:20]([N:1]2[CH2:5][CH2:4][CH:3]([C:6]([OH:8])=[O:7])[NH:2]2)=[O:21])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 867063391-Benzyl 2,3-di-tert-butyl pyrazolidine-1,2,3-tricarboxylate

생성물 1

HCID 537448401-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
25 °C

실험 절차

1-Benzyl 2,3-di-tert-butyl pyrazolidine-1,2,3-tricarboxylate (14.15 g, 34.8 mmol) was dissolved in dichloromethane (68.6 ml) under N2 at room temperature. TFA (80 ml, 1045 mmol) and water (9.41 ml, 522 mmol) were then added in one portion. The reaction was stirred at 25° C. for 2 days. The solvent was then removed under reduced pressure to give 1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid (8.72 g, 34.8 mmol, 100% yield).

후처리

  1. customThe solvent was then removed under reduced pressure

출처 및 근거

ORD 기록
ord-487101064b2246df8ad194520db99a28
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901119B2

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