関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 1-Benzyl 2,3-di-tert-butyl pyrazolidine-1,2,3-tricarboxylate | HCID 86706339 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid | HCID 53744840 | 100% |
反応手順
1-Benzyl 2,3-di-tert-butyl pyrazolidine-1,2,3-tricarboxylate (14.15 g, 34.8 mmol) was dissolved in dichloromethane (68.6 ml) under N2 at room temperature. TFA (80 ml, 1045 mmol) and water (9.41 ml, 522 mmol) were then added in one portion. The reaction was stirred at 25° C. for 2 days. The solvent was then removed under reduced pressure to give 1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid (8.72 g, 34.8 mmol, 100% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08901119B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-487101064b2246df8ad194520db99a28 |
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| 出典メモ | uspto-grants-2014_12 |
|---|
