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HRID 1396856作成日：2026年10月25日
Diisopropylethylamine → 2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid
https://huagongshe.com/reaction/1396856
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-(Benzyloxy carbonyl)pyrazolidine-3-carboxylic acid | HCID 53744840 | — |
| 反応物 | (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl fluoride | HCID 86706340 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid | HCID 86706341 | — |
反応手順
To a solution of (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl fluoride (3.24 g, 10.55 mmol) in DMF (30 mL) was added 1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid (2.2 g, 8.79 mmol) followed by DIPEA (3.07 mL, 17.58 mmol). The reaction was stirred at 25° C. for 18 hrs. The reaction was concentrated and purified by reverse-phase HPLC to afford 2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid as a mixture of diastereomers. LC-MS (ES) m/e 538.8 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08901119B2 |
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| 出典データセット | uspto-grants-2014_12 |
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| ORD ID | ord-d3bf29e7ae6b4d33bd1d7f18cae91c86 |
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| 出典メモ | uspto-grants-2014_12 |
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