反应详情

(3S)-2-[(2R)-3-Cyclopentyl-2 ({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-N-(5-fluoro-2-pyridinyl)-1-methyl-3-pyrazolidinecarboxamide (84 mg, 0.164 mmol) was dissolved in methanol (9.66 ml). To this mixture was added 20% palladium hydroxide on carbon (23.06 mg, 0.033 mmol). The reaction mixture was degassed and placed under 1 atm of H2. After 2 h, the reaction mixture was filtered and concentrated. The residue was purified by RP-HPLC to afford (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-(5-fluoro-2-pyridinyl)-1-methyl-3-pyrazolidinecarboxamide (40 mg, 0.095 mmol, 57.8% yield) as white foam solid. LC-MS (ES) m/e 422.1 (M+H)+.

1. customThe reaction mixture was degassed
2. filtrationthe reaction mixture was filtered
3. concentrationconcentrated
4. customThe residue was purified by RP-HPLC