反应详情

(3S)-2-[(2R)-3-Cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-methyl-N-[3-(methyloxy)-2-pyrazinyl]-3-pyrazolidinecarboxamide (96 mg, 0.183 mmol) was dissolved in methanol (11 mL). To this mixture was added 20% palladium hydroxide on carbon (26.8 mg, 0.038 mmol). The reaction mixture was degassed and placed under 1 atm of H2. After 1 h, the reaction mixture was filtered and concentrated. The residue was purified by RP-HPLC to afford (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-1-methyl-N-[3-(methyloxy)-2-pyrazinyl]-3-pyrazolidinecarboxamide (45 mg, 0.104 mmol, 54.3% yield) as white foam solid. LC-MS (ES) m/e 435.4 (M+H)+.

1. customThe reaction mixture was degassed
2. filtrationthe reaction mixture was filtered
3. concentrationconcentrated
4. customThe residue was purified by RP-HPLC