Dimethylamine → HCID 45080527, compound

HRID 1396905Notes

Reaction equation

HRID 1396905 reaction equation
[CH3:1][NH:2][CH3:3].O.Cl[C:6]1[N:11]=[C:10]([NH2:12])[CH:9]=[CH:8][N:7]=1>CN(C)C=O>[CH3:1][N:2]([CH3:3])[C:6]1[N:11]=[C:10]([NH2:12])[CH:9]=[CH:8][N:7]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 3457522-Chloro-4-aminopyrimidine

Product 1

HCID 45080527HCID 45080527, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
220 °C

Procedure

40% Dimethylamine in water (1466 μl, 11.58 mmol) was added into the mixture of 2-chloro-4-pyrimidinamine (300 mg, 2.316 mmol) in N,N-dimethylformamide (DMF) (1.5 ml). The resulting reaction mixture was heated in a microwave reactor at 220° C. for 30 min. The reaction mixture was purified by RP-HPLC to yield N,N-dimethyl-2,4-pyrimidinediamine (290 mg, 2.099 mmol, 91% yield) as a white solid. MS (ES+) m/z 139.2 (MH+).

Workup

  1. customThe resulting reaction mixture
  2. customThe reaction mixture was purified by RP-HPLC

Sources & evidence

ORD record
ord-63aa6645d869465dbeafc52016f79860
Source dataset
uspto-grants-2014_12
Patent number
US08901119B2

Reaction notes

Loading…