反应详情

To a solution of phenylmethyl (3S)-2-[(2R)-2-({formyl [(phenylmethyl)oxy]amino}methyl)hexanoyl]-3-[(2-pyridinylamino)carbonyl]-1-pyrazolidinecarboxylate (70 mg, 0.12 mmol) in EtOAc (6 mL) was added per carbamide (45 mg, 0.48 mmol) and 2-benzofuran-1,3-dione (71 mg, 0.48 mmol). The mixture was stirred overnight until TLC showed the completion of the reaction. The mixture was washed with aq. Na2CO3 and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash column chromatography to provide the titled compound (86 mg, 85%)

1. customthe completion of the reaction
2. washThe mixture was washed with aq. Na2CO3 and brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by flash column chromatography