反应详情

To a solution of 1,1-dimethylethyl (3R)-3-(cyclopentylmethyl)-4-(5-{[(6-ethyl-2-pyridinyl)amino]carbonyl}-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoate (359 mg, 0.79 mmol) in 1,4-dioxane (10.0 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (9.8 mL, 39 mmol) at room temperature. The reaction mixture was stirred for 5 hours. The solvent was then removed by reduced pressure to afford the crude product (3R)-3-(cyclopentyl methyl)-4-(5-{[(6-ethyl-2-pyridinyl)amino]carbonyl}-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (314 mg, 100%), which was used directly in the next step. MS: 401 ([M+H]+).

1. customThe solvent was then removed by reduced pressure