反应详情

To a solution of 1,1-dimethylethyl (3R)-3-(cyclopentylmethyl)-4-{5-[(dimethylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoate (315 mg, 0.83 mmol) in 1,4-dioxane (5.0 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (10.4 mL, 42 mmol) at room temperature. The reaction mixture was stirred for 4 hours. The solvent was then removed by reduced pressure to afford the crude product, (3R)-3-(cyclopentylmethyl)-4-{5-[(dimethylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid (269 mg, 100% yield), which was used directly in the next step. MS: 324 ([M+H]+).

1. customThe solvent was then removed by reduced pressure