Boronic Acid → 6-(4-(Trifluoromethyl)phenyl)picolinaldehyde

HRID 1397015Notes

Reaction equation

HRID 1397015 reaction equation
B(O)O.Br[C:5]1[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=1.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18]([C:5]2[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 247300896-(4-(Trifluoromethyl)phenyl)picolinaldehyde

Procedure

6-(4-(trifluoromethyl)phenyl)picolinaldehyde was prepared using the general boronic acid coupling procedure for 6-bromopicolinaldehyde and (4-(trifluoromethyl)phenyl)boronic acid (79 mg, 135.1 mg theoretical, 58.5%). LC-MS m/z 252.2 (M+1).

Sources & evidence

ORD record
ord-fdbe9384890749429f686a89666166b3
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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