Boronic Acid → HCID 86672844, compound

HRID 1397019Notes

Reaction equation

HRID 1397019 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[F:13][C:14]([F:24])([F:23])[C:15]1[S:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[F:13][C:14]([F:24])([F:23])[C:15]1[S:19][C:18]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 47149512-BromonicotinaldehydeHCID 45158752[5-(Trifluoromethyl)thiophen-2-yl]boronic acid

Product 1

HCID 86672844HCID 86672844, compound

Procedure

2-(5-(trifluoromethyl)thiophen-2-yl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (5-(trifluoromethyl)thiophen-2-yl)boronic acid (47.7 mg, 62.3 mg theoretical, 76.6%). LC-MS m/z 258.2 (M+1).

Sources & evidence

ORD record
ord-8f0a7cbd5ed1446687aab463ccfe693c
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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