Boronic Acid → 2-(3-Thienyl)-3-pyridinecarboxaldehyde

HRID 1397020Notes

Reaction equation

HRID 1397020 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[S:13]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14]1>>[S:13]1[CH:17]=[CH:16][C:15]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:14]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 581760Thiophene-3-boronic acidHCID 47149512-Bromonicotinaldehyde

Product 1

HCID 27645642-(3-Thienyl)-3-pyridinecarboxaldehyde

Procedure

2-(thiophen-3-yl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and thiophen-3-ylboronic acid (60 mg, 101.8 mg theoretical, 58.9%). LC-MS m/z 190.2 (M+1).

Sources & evidence

ORD record
ord-6cc2de8e7a2244b68eaf556dacea9461
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…