Boronic Acid → HCID 86672846, compound

HRID 1397022Notes

Reaction equation

HRID 1397022 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[C:13]([O:17][C:18]([N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1B(O)O)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[CH:7]([C:6]1[C:5]([C:21]2[N:20]([C:18]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:19])[CH:24]=[CH:23][CH:22]=2)=[N:12][CH:11]=[CH:10][CH:9]=1)=[O:8]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic AcidHCID 47149512-Bromonicotinaldehyde

Product 1

HCID 86672846HCID 86672846, compound

Procedure

tert-butyl 2-(3-formylpyridin-2-yl)-1H-pyrrole-1-carboxylate was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (1-(tert-butoxycarbonyl)-1H-pyrrol-2-yl)boronic acid (66 mg, 146.5 mg theoretical, 45.1%). LC-MS m/z 273.3 (M+1).

Sources & evidence

ORD record
ord-bbb3acdac2ca4248aa630774f7c0239b
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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