Boronic Acid → HCID 86672852, compound

HRID 1397031Notes

Reaction equation

HRID 1397031 reaction equation
B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=1)[CH:8]=[O:9].[F:13][C:14]([F:24])([F:23])[C:15]1[S:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[F:13][C:14]([F:24])([F:23])[C:15]1[S:19][C:18]([C:5]2[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=2)[CH:8]=[O:9])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27629912-Bromo-4-pyridinecarboxaldehydeHCID 45158752[5-(Trifluoromethyl)thiophen-2-yl]boronic acid

Product 1

HCID 86672852HCID 86672852, compound

Procedure

2-(5-(trifluoromethyl)thiophen-2-yl)isonicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromoisonicotinaldehyde and (5-(trifluoromethyl)thiophen-2-yl)boronic acid (29.4 mg, 62.3 mg theoretical, 47.2%). LC-MS m/z 258.2 (M+1).

Sources & evidence

ORD record
ord-e2ef1f781ab14462bdfb26c676266101
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…