Boronic Acid → HCID 86672854, compound

HRID 1397033Notes

Reaction equation

HRID 1397033 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[F:13][C:14]([F:26])([F:25])[O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1>>[F:13][C:14]([F:25])([F:26])[O:15][C:16]1[CH:21]=[C:20]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 47149512-Bromonicotinaldehyde

Product 1

HCID 86672854HCID 86672854, compound

Procedure

2-(3-(trifluoromethoxy)phenyl)nicotinaldehyde was prepared using the general boronic acid coupling procedure with 2-bromonicotinaldehyde and (3-(trifluoromethoxy)phenyl)boronic acid (101 mg, 144 mg theoretical, 70.1%). LC-MS m/z 268 (M+1).

Sources & evidence

ORD record
ord-96d6d6bade004b378d7235d65ce636f0
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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