Boronic Acid → [3,3'-Bithiophene]-5-carbaldehyde

HRID 1397034Notes

Reaction equation

HRID 1397034 reaction equation
B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[O:11])[S:8][CH:9]=1.[S:12]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13]1>>[S:8]1[C:7]([CH:10]=[O:11])=[CH:6][C:5]([C:14]2[CH:15]=[CH:16][S:12][CH:13]=2)=[CH:9]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 877924-Bromothiophene-2-carbaldehydeHCID 581760Thiophene-3-boronic acid

Product 1

HCID 16218061[3,3'-Bithiophene]-5-carbaldehyde

Procedure

[3,3′-bithiophene]-5-carbaldehyde was prepared using the general boronic acid coupling procedure with 4-bromothiophene-2-carbaldehyde and thiophen-3-ylboronic acid (56 mg, 102 mg theoretical, 54.9%). LC-MS m/z 195 (M+1).

Sources & evidence

ORD record
ord-fd9ad87ec7a24e0eba456bd77b4da529
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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