反应详情

To a solution of 4′-(cyclopropylmethyl)-2-(methylsulfinyl)-4,5′-bipyrimidin-2′-amine (5-2) (50 mg, 0.173 mmol) in DMSO (1 ml), was added Tetrahydro-pyran-3-ylamine HCl (119 mg, 0.864 mmol) and triethylamine (0.120 ml, 0.864 mmol) and the reaction was microwaved for 45 min at 160° C. The reaction was purified directly by reverse phase HPLC with a gradient of 10-90% acetonitrile in water over 15 minutes and then further purified by flash chromatography with a gradient of 25-100% ethyl acetate in heptane to give the desired product as a white solid (7.36 mg).

1. customthe reaction was microwaved for 45 min at 160° C
2. customThe reaction was purified directly by reverse phase HPLC with a gradient of 10-90% acetonitrile in water over 15 minutes
3. customfurther purified by flash chromatography with a gradient of 25-100% ethyl acetate in heptane