2-Bromoacetamidopyridine → HCID 24699189, compound

HRID 1397234Notes

Reaction equation

HRID 1397234 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)=O.[C:11]([CH2:13][C:14]([NH2:16])=[S:15])#[N:12]>>[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3]1[N:16]=[C:14]([CH2:13][C:11]#[N:12])[S:15][CH:2]=1

Participants

3

Reactant 2

HCID 383842-BromoacetamidopyridineHCID 14162772-Cyanoethanethioamide

Product 1

HCID 24699189HCID 24699189, compoundYield 73%

Procedure

This compound was synthesized from 2-bromo-1-(pyridin-2-yl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (0.37 g, yield 73%): 1H NMR (400 MHz, CDCl3) δ 8.65 (d, J=5.5 Hz, 1H), 8.15 (m, 2H), 7.84 (t, J=8.4 Hz, 1H), 7.30 (m, 1H), 4.21 (s, 2H). MS (ESI) m/z: Calculated for C10H7N3S: 201.04. found: 202.2 (M+H)+.

Sources & evidence

ORD record
ord-028af488c5fc4d82874916dddc5f6e8e
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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