HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(pyridin-4-yl)ethanone → 2-[4-(Pyridin-4-YL)-1,3-thiazol-2-YL]acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(pyridin-4-yl)ethanone | HCID 407031 | — |
| Reactant | 2-Cyanoethanethioamide | HCID 1416277 | — |
| Product | 2-[4-(Pyridin-4-YL)-1,3-thiazol-2-YL]acetonitrile | HCID 24710447 | 46% |
Reaction Steps
This compound was synthesized from 2-bromo-1-(pyridin-4-yl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (0.23 g, yield 46%): 1H NMR (300 MHz, MeOD) δ 8.59 (m, 2H), 8.24 (s, 1H), 7.98 (m, 2H), 4.44 (s, 2H). MS (ESI) m/z: Calculated for C10H7N3OS: 201.01. found: 202.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a5d17cc95da94bd18a961cda1451e344 |
| Source note | uspto-grants-2014_12 |