2-Bromo-4'-(trifluoromethyl)acetophenone → HCID 2742458, compound

HRID 1397267Notes

Reaction equation

HRID 1397267 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=O.[C:15]([CH2:17][C:18]([NH2:20])=[S:19])#[N:16]>>[F:12][C:11]([F:14])([F:13])[C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:20]=[C:18]([CH2:17][C:15]#[N:16])[S:19][CH:2]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 14162772-Cyanoethanethioamide

Product 1

HCID 2742458HCID 2742458, compoundYield 48%

Procedure

This compound was synthesized from 2-bromo-1-(4-(trifluoromethyl)phenyl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (2.4 g, 48% yield), and it was carried through without further purification. MS (ESI) m/z: Calculated for C12H7F3N2S: 268.03. found: 269.0 (M+H)+.

Workup

  1. customwas carried through without further purification

Sources & evidence

ORD record
ord-7e5d1bda92664ea1a5f4accf8ea32e89
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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