反应详情

Hydrazine hydrate (1.8 mL, 35 mmol) was added to a solution of methyl 2-cyano-2-methylpropanoate (5.0 g, 35.0 mmol) in EtOH (5 mL), and the reaction mixture was stirred at room temperature for 1 h (monitored by TLC, eluant petroleum ether:EtOAc 7:3 v/v). The reaction mixture was diluted with diethyl ether and the precipitate formed was filtered. The clear filtrate was concentrated under reduced pressure to get 2-cyano-2-methylpropanehydrazide (1.75 g, yield 38%), which was carried through without further purification. MS (ESI) m/z: Calculated for C5H9N3O: 127.07. found: 128.2 (M+H)+.

1. customthe precipitate formed
2. filtrationwas filtered
3. concentrationThe clear filtrate was concentrated under reduced pressure