Triethylamine → HCID 67324319, compound

HRID 1397323Notes

Reaction equation

HRID 1397323 reaction equation
[C:1]([C:3]([CH3:9])([CH3:8])[C:4]([NH:6][NH2:7])=O)#[N:2].CCN(CC)CC.Cl.[C:18](=[NH:27])(OC)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CO>[CH3:8][C:3]([C:4]1[NH:6][N:7]=[C:18]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:27]=1)([CH3:9])[C:1]#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 5743287Methyl benzimidate hydrochlorideHCID 866749212-Cyano-2-methylpropanehydrazide

Product 1

HCID 67324319HCID 67324319, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Cyano-2-methylpropanehydrazide (100 mg, 0.78 mmol) and Et3N (0.1 mL, 0.86 mmol) were added to a solution of methyl benzimidate hydrochloride (100 mg, 0.58 mmol) in dry MeOH (10 mL), and the mixture was heated to reflux for 1 h. The reaction mixture was then concentrated under reduced pressure and the crude product was purified by column chromatography (silica 60-120 mesh, eluant 15% EtOAc in petroleum ether) to get 2-methyl-2-(3-phenyl-1H-1,2,4-triazol-5-yl)propanenitrile (80 mg, yield 51%). 1H NMR (300 MHz, MeOD) δ 7.98-7.95 (m, 2H), 7.52-7.50 (m, 3H), 1.82 (s, 6H). MS (ESI) m/z: Calculated for C12H12N4: 212.11. found: 213.2 (M+H)+.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 1 h
  3. concentrationThe reaction mixture was then concentrated under reduced pressure
  4. customthe crude product was purified by column chromatography (silica 60-120 mesh, eluant 15% EtOAc in petroleum ether)

Sources & evidence

ORD record
ord-cad848bcb19348caa730eb123879408e
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

Loading…