HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-fluorobenzimidate hydrochloride → 2-(3-(4-fluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methylpropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-fluorobenzimidate hydrochloride | HCID 14685563 | — |
| Reactant | 2-Cyano-2-methylpropanehydrazide | HCID 86674921 | — |
| Product | 2-(3-(4-fluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methylpropanenitrile | HCID 67322546 | 70% |
Reaction Steps
This compound was synthesized from 2-cyano-2-methylpropanehydrazide and methyl 4-fluorobenzimidate hydrochloride as described in example 64 step 3 (300 mg, yield 70%). 1H NMR (300 MHz, MeOD) δ 8.03-7.98 (m, 2H), 7.29-7.23 (m, 2H), 1.81 (s, 6H). MS (ESI) m/z: Calculated for C12H11FN4: 230.10. found: 231.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5580af346e1f451fa7ab816c0d45d53d |
| Source note | uspto-grants-2014_12 |