HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Carboxypyridine-3-boronic acid → 5-(5-(2,2,2-Trifluoroacetyl)thiophen-2-yl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Carboxypyridine-3-boronic acid | HCID 3560503 | — |
| Reactant | 1-(5-Bromothiophen-2-yl)-2,2,2-trifluoroethan-1-one | HCID 19971587 | — |
| Product | 5-(5-(2,2,2-Trifluoroacetyl)thiophen-2-yl)nicotinic acid | HCID 67325504 | 82% |
Reaction Steps
This compound was synthesized from 1-(5-bromothiophen-2-yl)-2,2,2-trifluoroethanone and 5-borononicotinic acid as described in example 88 step 3 (470 mg, yield 82%). 1H NMR (300 MHz, DMSO-d6) δ 13.74 (br s, 1H), 9.30-9.29 (s, 1H), 9.11-9.10 (m, 1H), 8.59-8.58 (t, J=2.0 Hz, 1H), 8.20-8.19 (m, 1H), 8.07-8.05 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-52544b810d914fa2bb7a372683d121a1 |
| Source note | uspto-grants-2014_12 |