2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine → N-(2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropyl)-2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)oxazole-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine	HCID 67323086	—
Reactant	2-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)oxazole-4-carboxylic acid	HCID 67323977	—
Product	N-(2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropyl)-2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)oxazole-4-carboxamide	HCID 71212768	13%

Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine and 2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)oxazole-4-carboxylic acid as described in example 8 step 6 (6 mg, yield 13%). 1H NMR (400 MHz, CDCl3) δ 8.88-8.86 (m, 1H), 8.49 (s, 1H), 8.25-8.21 (m, 2H), 7.46 (s, 1H), 7.23-7.19 (t, J=8.8 Hz, 2H), 3.62-3.60 (d, J=6.0 Hz, 2H), 1.39 (s, 6H). MS (ESI) m/z: Calculated for C20H15F4N6O4: 465.11. found: 466.1 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08901156B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-694a15136ca44eb09c29273a917866ca
Source note	uspto-grants-2014_12