反应详情

This compound was synthesized from 5-(N′-hydroxycarbamimidoyl)nicotinic acid using ethyl difluoroacetate as described in example 1 step 5 (100 mg, yield 30%). 1H NMR (400 MHz, DMSO-d6) δ 13.94 (br s, 1H), 9.40 (d, J=2.1 Hz, 1H), 9.28 (d, J=2.1 Hz, 1H), 8.76-8.75 (t, J=2.1 Hz, 1H), 7.73-7.47 (m, 1H). MS (ESI) m/z: Calculated for C9H6F2N3O3: 241.03. found: 241.8 (M+H)+.