HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl difluoroacetate → 5-(5-(Difluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl difluoroacetate | HCID 9961 | — |
| Reactant | 5-(N'-hydroxycarbamimidoyl)nicotinic acid | HCID 86677596 | — |
| Product | 5-(5-(Difluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid | HCID 67323936 | 30% |
Reaction Steps
This compound was synthesized from 5-(N′-hydroxycarbamimidoyl)nicotinic acid using ethyl difluoroacetate as described in example 1 step 5 (100 mg, yield 30%). 1H NMR (400 MHz, DMSO-d6) δ 13.94 (br s, 1H), 9.40 (d, J=2.1 Hz, 1H), 9.28 (d, J=2.1 Hz, 1H), 8.76-8.75 (t, J=2.1 Hz, 1H), 7.73-7.47 (m, 1H). MS (ESI) m/z: Calculated for C9H6F2N3O3: 241.03. found: 241.8 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-884a746a49194b90b52da1553a5fc540 |
| Source note | uspto-grants-2014_12 |