2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine → HCID 69950218, compound

HRID 1397442Notes

Reaction equation

HRID 1397442 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][NH2:15])[N:12]=2)=[CH:4][CH:3]=1.[F:18][C:19]([F:35])([F:34])[C:20]1[O:24][N:23]=[C:22]([C:25]2[CH:26]=[N:27][CH:28]=[C:29]([CH:33]=2)[C:30](O)=[O:31])[N:21]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][NH:15][C:30](=[O:31])[C:29]3[CH:33]=[C:25]([C:22]4[N:21]=[C:20]([C:19]([F:35])([F:34])[F:18])[O:24][N:23]=4)[CH:26]=[N:27][CH:28]=3)[N:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 673230862-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amineHCID 673242165-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid

Product 1

HCID 69950218HCID 69950218, compoundYield 13%

Procedure

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine and 5-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-nicotinic acid as described in example 8 step 6 (19 mg, yield 13%). 1H NMR (400 MHz, MeOD) δ 9.38 (d, J=1.5 Hz, 1H), 9.17 (d, J=1.8 Hz, 1H), 8.84 (d, J=1.8 Hz, 1H), 8.09-8.05 (m, 2H), 7.78 (s, 1H), 7.25-7.20 (m, 2H), 3.68 (s, 2H), 1.42 (s, 6H). MS (ESI) m/z: Calculated for C22H17F4N5O3: 475.13. found: 476.2 (M+H)+.

Sources & evidence

ORD record
ord-9209f95a57114b899771d7ee554138f6
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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